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Description: ML141 (also known as CID-2950007) is a novel potent, selective and reversible non-competitive inhibitor of Rho family GTPase cdc42 with IC50 of 200 nM. ML141 enhances the ability of TMX to suppress BLBC cell growth through both induction of cell death and suppression of cell division. ML141 also significantly protects neuroblastoma cells from metformin-induced apoptosis. Moreover, ML141 diminishes K. pneumoniae invasion in a dose-dependent manner.
References: Oncotarget. 2014 Nov 30; 5(22):11709-22; EMBO Mol Med. 2013 May; 5(5):723-36.
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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