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eht-1864-hcl

eht-1864-hcl

Item no.	V1566-250mg
Manufacturer	InvivoChem LLC
CASRN	754240-09-0
Amount	250mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 5.1	32160401
ECLASS 6.1	32160405
ECLASS 8.0	32160490
ECLASS 9.0	32160490
ECLASS 10.0.1	32160490
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1566CAS #:754240-09-0Purity >=98% Description: EHT 1864 dihydrochloride is a potent and novel Rac family GTPase inhibitor with Kd of 40 nM, 50 nM, 60 nM and 250 nM for Rac1, Rac1b, Rac2 and Rac3, respectively. EHT 1864 attenuates glucose-stimulated insulin secretion in pancreatic beta-cells. EHT 1864 specifically inhibits glucose-induced Rac1 activation and membrane association and associated downstream signaling events culminating in inhibition of GSIS. References: J Biol Chem. 2007 Dec 7; 282(49):35666-78; J Biol Chem. 2005 Nov 11; 280(45):37516-25. Related CAS#: CAS#754240-09-0 (dihydrochloride); 754239-64-0 (free base)
Molecular Weight (MW)	581.47
Formula	C25H29Cl2F3N2O4S
CAS No.	754240-09-0
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (172.0 mM)
	Water: 100 mg/mL (172.0 mM)
	Ethanol: < 1 mg/mL
SMILES	O=C1C=C(CN2CCOCC2)OC=C1OCCCCCSC3=CC=NC4=CC(C(F)(F)F)=CC=C34
Synonyms	EHT-1864; EHT1864; EHT 1864 HCl

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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