ml167

Item no.	V1545-5mg
Manufacturer	InvivoChem LLC
CASRN	1285702-20-6
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1285702-20-6
Available
Description	InvivoChem Cat #:V1545CAS #:1285702-20-6Purity >=98% Description: ML167 (also known as CID 44968231; NCGC00188654) is a novel and highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, > 10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B. ML167 is found as the first fully selective inhibitor of Clk4 but not other related kinases including Clk1, Clk2 and Clk3 and Dyrk1A/1B. It is 10-fold more potent against Clk4 over other kinases. The treatment of ML167 on Caco-2 cells proves that ML167 is highly cell-permeable. Besides that, ML167 is also found to be an ATP-competitive inhibitor References: Rosenthal A S, Tanega C, Shen M, et al. An inhibitor of the Cdc2-like kinase 4 (Clk4). 2011.
Molecular Weight (MW)	335.36
Formula	C19H17N3O3
CAS No.	1285702-20-6
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 67 mg/mL (199.8 mM)
	Water: < 1 mg/mL
	Ethanol: 13 mg/mL (38.8 mM)
SMILES	OCC1=CC=C(C2=CC3=C(NCC4=CC=C(C)O4)N=CN=C3C=C2)O1
Synonyms	CID 44968231; CID44968231; CID-44968231; NCGC00188654; NCGC-00188654; NCGC 00188654; ML167; ML-167; ML 167

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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