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xl413-bms-863233

xl413-bms-863233

Item no.	V1543-500mg
Manufacturer	InvivoChem LLC
CASRN	1169562-71-3
Amount	500mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1543CAS #:1169562-71-3Purity >=98% Description: XL413 HCl (BMS-863233) is a novel, highly potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor with IC50 of 3.4 nM, it shows 63-, 12- and 35-fold selectivity over CK2, Pim-1 and pMCM2, respectively. In MDA-MB-231T and Colo-205 cell lines, XL413 results in inhibition of CDC7 specific phosphorylation of MCM2. XL413 also inhibits the cell proliferation, decreases cell viability and elicits the caspase 3/7 activity in Colo-205 cells. Moreover, XL413 results in modified S phase progression that subsequently leads to apoptotic cell death. References: Bioorg Med Chem Lett. 2012 Jun 1; 22(11):3727-31. Related CAS #: 1169562-71-3 (HCl) 1169558-38-6 (free base)
Molecular Weight (MW)	326.18
Formula	C14H13Cl2N3O2
CAS No.	1169562-71-3
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: < 1 mg/mL
	Water: 46 mg/mL (141.02 mM)
	Ethanol: < 1 mg/mL
Other info	Chemical Name: (S)-8-chloro-2-(pyrrolidin-2-yl)benzofuro[3, 2-d]pyrimidin-4(3H)-one hydrochloride InChi Key: UNDKJUKLBNARIZ-FVGYRXGTSA-N InChi Code: InChI=1S/C14H12ClN3O2.ClH/c15-7-3-4-10-8(6-7)11-12(20-10)14(19)18-13(17-11)9-2-1-5-16-9; /h3-4, 6, 9, 16H, 1-2, 5H2, (H, 17, 18, 19); 1H/t9-; /m0./s1 SMILES Code: O=C1C(OC2=CC=C(Cl)C=C23)=C3N=C([CH]4NCCC4)N1.[H]Cl
Synonyms	XL413; XL-413; XL 413; BMS863233; BMS-863233; BMS 863233.

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Amount: 500mg

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Delivery expected until 9/6/2024