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encenicline-hcl-salt

encenicline-hcl-salt

Item no.	V15400-25mg
Manufacturer	InvivoChem LLC
CASRN	550999-74-1
Amount	25mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V15400CAS #:550999-74-1Purity >=98% Description: Encenicline (EVP-6124; MT-4666) is a novel partial agonist of alpha7 nicotinic acetylcholine receptor. EVP-6124 enhances dopamine, acetylcholine, and glutamate efflux in rat cortex and nucleus accumbens. EVP-6124 improves memory performance by potentiating the acetylcholine response of alpha7 nicotinic acetylcholine receptors. References: 1. PrickaertsJ, et al. EVP-6124, a novel and selective alpha7 nicotinic acetylcholinereceptor partial agonist, improves memory performance by potentiatingthe acetylcholine response of alpha7 nicotinic acetylcholine receptors.Neuropharmacology. 2012 Feb; 62(2):109 2. ThomasPapouin, et al. Septal Cholinergic Neuromodulation Tunes theAstrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness.Neuron. 2017 May 17; 94:1-15. 3. PapouinT, et al. Septal Cholinergic Neuromodulation Tunes theAstrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness.Neuron. 2017 May 17; 94(4):840-854.e7. 4. MaeharaS, et al. Pharmacological characterization of a novel potent, selective, and orally active phosphodiesterase 2A inhibitor, PDM-631.Eur J Pharmacol. 2017 Sep 15; 811:110-116. 5. PCP-induced deficits in murine nest building activity: Employment of an ethological rodent behavior to mimic negative-like symptoms of schizophrenia. Behav Brain Res. 2014 Jul 24. pii: S0166-4328(14)00472-0. Related CAS #: 550999-75-2 (free base); 550999-74-1 (HCl)

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Amount: 25mg

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