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purvalanol-a

purvalanol-a

Manufacturer	InvivoChem LLC
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
Amount	10mg
Item no.	V1540-10mg
CASRN	212844-53-6
eClass 6.1	32160405
eClass 9.0	32160490
Available
Alias	212844-53-6
Description	InvivoChem Cat #:V1540CAS #:212844-53-6Purity >=98% Description: Purvalanol A is a potent and cell-permeable CDK inhibitor with IC50 of 4 nM, 70 nM, 35 nM, and 850 nM for cdc2-cyclin B, cdk2-cyclin A, cdk2-cyclin E, and cdk4-cyclin D1, respectively. In MKN45 cells, purvalanol A (30 uM) reduced the expression of antiapoptotic proteins Bcl-2, Bcl-XL and survivin and induced apoptosis. Also, purvalanol A inhibited the phosphorylation of STAT3 by Janus kinase 2 (JAK2) and the expression and phosphorylation of RNA polymerase II, which was involved in transcriptional regulation. References: Science. 1998; 281(5376):533-8; Mol Biol Rep. 2014; 41(1):145-54; Genes Cells. 2010; 15(10):1051-62. Related CAS: 212844-54-7 (Purvalanol B); 220792-57-4 (Aminopurvalanol A); 212844-53-6 (Purvalanol A)
Molecular Weight (MW)	388.89
Formula	C19H25ClN6O
CAS No.	212844-53-6
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 60 mg/mL (154.3 mM)
	Water: < 1 mg/mL
	Ethanol: 13 mg/mL (33.4 mM)
Other info	Chemical Name: (R)-2-((6-((3-chlorophenyl)amino)-9-isopropyl-9H-purin-2-yl)amino)-3-methylbutan-1-ol InChi Key: PMXCMJLOPOFPBT-HNNXBMFYSA-N InChi Code: InChI=1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8, 10-12, 15, 27H, 9H2, 1-4H3, (H2, 22, 23, 24, 25)/t15-/m0/s1 SMILES Code: CC(C)[CH](NC1=NC(NC2=CC=CC(Cl)=C2)=C3N=CN(C(C)C)C3=N1)CO
Synonyms	NG60; NG-60; NG 60

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