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Description: Go 6983 (also known as GOE 6983) is a novel and potent pan-PKC (protein kinase C) inhibitor against PKCalpha, PKCbeta, PKCgamma and PKCdelta with IC50 of 7 nM, 7 nM, 6 nM and 10 nM, respectively; it is less potent to PKCzeta and is inactive on PKCu. GO6893 displays cardioprotective properties and can reduce polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. When tested with MCF-7 and T47D cells, Go 6983 showed reversible effect on the down-regulation of PKCalphaand PKCdelta induced by PKC activator PDBu, while decreased the expression of PKCeta which up-regulated by PDBu.
References: FEBS Lett. 1996 Aug 26; 392(2):77-80; J Cardiovasc Pharmacol. 2004 May; 43(5):645-56.
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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