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gw842166x

gw842166x

Item no.	V1519-10mg
Manufacturer	InvivoChem LLC
CASRN	666260-75-9
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1519CAS #:666260-75-9Purity >=98% Description: GW842166X is a novel, potent and highly selective agonist of cannabinoid receptor CB2 receptor with EC50 of 63 nM and with the potential for the treatment of inflammatory pain, it shows little activity on CB1 receptor. GW842166X shows similar potency and efficacy for rat and human recombinant CB2 receptors with EC50 of 91 nM and 63nM, respectively. GW-842166X exhibits full agonist potency with an EC50 of 133 nM and Emax of 101% in cyclase assays. IT exhibits weak agonist potency with an EC50 of 7.780 uM and Emax of 84% in FLIPR assays. Description: References: J Med Chem. 2007 May 31; 50(11):2597-600; Br J Pharmacol. 2008 Jan; 153(2):390-401 References:
Molecular Weight (MW)	449.25
Formula	C18H17Cl2F3N4O2
CAS No.	666260-75-9
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 20 mg/mL (44.5 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	30% Propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL
Technical info	Synonym: GW-842166X; 842166X; 842166; GW-842166; GW842166X; GW842166; GW 842166X; GW 842166 IUPAC/Chemical Name: 2-((2, 4-dichlorophenyl)amino)-N-((tetrahydro-2H-pyran-4-yl)methyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide InChi Key: TWQYWUXBZHPIIV-UHFFFAOYSA-N InChi Code: InChI=1S/C18H17Cl2F3N4O2/c19-11-1-2-14(13(20)7-11)26-17-25-9-12(15(27-17)18(21, 22)23)16(28)24-8-10-3-5-29-6-4-10/h1-2, 7, 9-10H, 3-6, 8H2, (H, 24, 28)(H, 25, 26, 27) SMILES Code: O=C(C1=CN=C(NC2=CC=C(Cl)C=C2Cl)N=C1C(F)(F)F)NCC3CCOCC3

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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