« Back
Home /
macitentan

macitentan

Item no.	V1510-100mg
Manufacturer	InvivoChem LLC
CASRN	441798-33-0
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1510CAS #:441798-33-0Purity >=98% Description: Macitentan (also known as ACT 064992; trade name Opsumit) is a potent, orally bioactive, non-peptide, dual ETA/ETB endothelin (ET) receptor antagonist approved for the treatment of pulmonary arterial hypertension (PAH). It has mean IC50 values of 0.5 +/- 0.2 nM (n= 17) to inhibit the binding of 125I-ET-1 to recombinant ETA receptors, and of 391+/-182 nM (n= 17) for ETB receptors in Chinese hamster ovary cells. In microsomal membranes of human-ETA and ETB-overexpressing Chinese hamster ovary cells, macitentan inhibited the binding between 125I-ET-1 and recombinant ETA receptors, with a mean IC50 value of 0.5 +/- 0.2 nM (n= 17). Description: References: J Pharmacol Exp Ther. 2008 Dec; 327(3):736-45; Life Sci. 2012 Oct 15; 91(13-14):658-68. References: Related CAS: 556797-16-1 (Macitentan n-butyl analogue); 1258428-05-5 Macitentan D4 (ACT-064992 D4)
Molecular Weight (MW)	588.27
Formula	C19H20Br2N6O4S
CAS No.	441798-33-0
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (170.0 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: N-[5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl]-N'- propylsulfamide InChi Key: JGCMEBMXRHSZKX-UHFFFAOYSA-N InChi Code: InChI=1S/C19H20Br2N6O4S/c1-2-7-26-32(28, 29)27-17-16(13-3-5-14(20)6-4-13)18(25-12-24-17)30-8-9-31-19-22-10-15(21)11-23-19/h3-6, 10-12, 26H, 2, 7-9H2, 1H3, (H, 24, 25, 27) SMILES Code: O=S(NCCC)(NC1=NC=NC(OCCOC2=NC=C(Br)C=N2)=C1C3=CC=C(Br)C=C3)=O
Synonyms	ACT 064992; ACT-064992; ACT064992; Macitentan; trade name: Opsumit.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 100mg

available

Delivery expected until 9/6/2024

Express Delivery: Save 14 days

Compare

Add to wishlist

Recommend by mail