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canagliflozin

canagliflozin

Item no.	V1499-50mg
Manufacturer	InvivoChem LLC
CASRN	842133-18-0
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1499CAS #:842133-18-0Purity >=98% Description: Canagliflozin (formerly TA-7284; JNJ-24831754ZAE; JNJ 28431754-AAA; JNJ-28431754; brand name Invokana) is a highly potent and selective SGLT2 (sodium-glucose transport protein) inhibitor with anti-diabetic activity. Canagliflozin has been approved by FDA for the treatment of type 2 diabetes. It inhibits hSGLT2 with an IC50 of 2.2 nM in a cell-free assay, and exhibits > 413-fold selectivity over hSGLT1. Description: References: PLoS One. 2012; 7(2):e30555; J Med Chem. 2010 Sep 9; 53(17):6355-60 References: Related CAS#: 928672-86-0 (hemihydrate); 842133-18-0 (free)
Molecular Weight (MW)	444.52
Formula	C24H25FO5S
CAS No.	842133-18-0 (free);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 88 mg/mL (198.0 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	0.5% CMC+0.25% Tween 80: 18 mg/mL
Synonyms	JNJ 28431754; JNJ24831754AAA; JNJ24831754ZAE; TA 7284; JNJ 24831754; JNJ-24831754; TA-7284; TA7284;

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