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tolvaptan

tolvaptan

Item no.	V1485-100mg
Manufacturer	InvivoChem LLC
CASRN	150683-30-0
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1485CAS #:150683-30-0Purity >=98% Description: Tolvaptan (formerly OPC41061; OPC-41061; trade names Samsca; Jinarc; Resodim) is a selective, competitive, orally bioavailable and nonpeptide antagonist of arginine vasopressin V2 receptor with anti-hypernatremic activity. It inhibits arginine vasopressin V2 receptor with an IC50 of 3 nM. Tolvaptan was approved for use in the treatment of hyponatremia. Tolvaptan is vasopressin receptor 2 antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH). Description: References: Cardiovasc Drug Rev. 2007 Spring; 25(1):1-13; Biochem Pharmacol. 2008 Mar 15; 75(6):1322-30. References:
Molecular Weight (MW)	448.94
Formula	C26H25ClN2O3
CAS No.	150683-30-0
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 90 mg/mL (200.5 mM)
	Water: < 1 mg/mL
	Ethanol: 6 mg/mL (13.4 mM)
Other info	Chemical Name: N-(4-{[(5R)-7-chloro-5-hydroxy-2, 3, 4, 5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl}-3-methylphenyl)-2-methylbenzamide InChi Key: GYHCTFXIZSNGJT-XMMPIXPASA-N InChi Code: InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4, 6-7, 9-12, 14-15, 24, 30H, 5, 8, 13H2, 1-2H3, (H, 28, 31)/t24-/m1/s1 SMILES Code: O=C(NC1=CC=C(C(N2CCC[CH](O)C3=CC(Cl)=CC=C32)=O)C(C)=C1)C4=CC=CC=C4C
Synonyms	OPC41061; Tolvaptan; OPC 41061; OPC-41061; trade names Samsca; Jinarc; Resodim.

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Amount: 100mg

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