si113

Description: SI113, a novel, potent and specific inhibitor of the Sgk1 kinase, is also able to strongly and consistently block, in vitro and in vivo, growth and survival of human hepatocellular-carcinomas, either used as a single agent or in combination with ionizing radiations. In the present paper we aim to study the effect of SI113 on human GBM cell lines with variable p53 expression. SI113 strongly affected the PI3K/mTOR pathway, evoking a pro-survival autophagic response in neurospheres.

References: Abbruzzese C, Catalogna G, Gallo E, di Martino S, Mileo AM, Carosi M, Dattilo V, Schenone S, Musumeci F, Lavia P, Perrotti N, Amato R, Paggi MG. The small molecule SI113 synergizes with mitotic spindle poisons in arresting the growth of human glioblastoma multiforme. Oncotarget. 2017 Nov 18; 8(67):110743-110755. doi: 10.18632/oncotarget.22500. eCollection 2017 Dec 19.