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trifluridine

trifluridine

Item no.	V1461-100mg
Manufacturer	InvivoChem LLC
CASRN	70-00-8
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1461CAS #:70-00-8Purity >=98% Description: Trifluridine (also known as trifluorothymidine; FTD; NSC-529182; NSC-75520; NSC529182; NSC75520; Viroptic), an inhibitor of the thymidylate synthase and DNA synthesis, is an approved anti-herpesvirus antiviral agent/medications used mainly for treating infections in the eye. It is a nucleoside and idoxuridine analogue as well as a modified form of deoxyuridine, which is similar enough to be incorporated into viral DNA replication, but the -CF3 group added to the uracil component blocks base pairing. It is one of the two components of the experimental anti-cancer drug TAS-102. Description: References: Cancer Chemother Pharmacol. 2015 Aug; 76(2):325-33; Invest Ophthalmol Vis Sci. 1989 Apr; 30(4):678-83. References:
Molecular Weight (MW)	296.2
Formula	C10H11F3N2O5
CAS No.	70-00-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 59 mg/mL (199.2 mM)
	Water: 59 mg/mL (199.2 mM)
	Ethanol: 59 mg/mL (199.2 mM)
Other info	Chemical Name: 1-((2R, 4S, 5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(trifluoromethyl)pyrimidine-2, 4(1H, 3H)-dione. InChi Key: VSQQQLOSPVPRAZ-RRKCRQDMSA-N InChi Code: InChI=1S/C10H11F3N2O5/c11-10(12, 13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2, 5-7, 16-17H, 1, 3H2, (H, 14, 18, 19)/t5-, 6+, 7+/m0/s1 SMILES Code: O=C1NC(C(C(F)(F)F)=CN1[CH]2O[CH](CO)[CH](O)C2)=O
Synonyms	FTD; NSC 529182; NSC 75520; NSC-529182; NSC-75520; NSC529182; NSC75520; Viroptic; 2-Deoxy-5-trifluoromethyluridine; Trifluridine; 5-Trifluorothymidine

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Amount: 100mg

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