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clofarabine

clofarabine

Item no.	V1451-500mg
Manufacturer	InvivoChem LLC
CASRN	123318-82-1
Amount	500mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1451CAS #:123318-82-1Purity >=98% Description: Clofarabine(formerly C1 F-Ara-A; C1 F-Ara-A; CAFdA; trade names: Clofarex; Clolar) is an antimetabolite anticancer chemotherapeutic drug and a purine nucleoside approved for the treatment of relapsed or refractory acute lymphoblastic leukemia. It acts as a DNA synthesis inhibitor as well as a substrate of Deoxycytidine kinase (dCK). Clofarabine is phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase-alpha and -epsilon. At the same time, clofarabine-monophosphate is incorporated into internal and terminal DNA sites, which impaired DNA elongation and repair. Clofarabine triphosphate inhibits ribonucleotide reductase with IC50 value of 65 nM, which then reduced dCTP and dATP. Clofarabine is efficiently transported into cells through nucleoside transporters hENT1, hENT2, and hCNT2. Description: References: Nat Rev Drug Discov. 2006 Oct; 5(10):855-63; Clin Cancer Res. 2001 Nov; 7(11):3580-9. References:
Molecular Weight (MW)	303.68
Formula	C10H11ClFN5O3
CAS No.	123318-82-1
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 60 mg/mL (197.6 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	Chemical Name: (2S, 3S, 4R, 5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol InChi Key: WDDPHFBMKLOVOX-IETYGKGOSA-N InChi Code: InChI=1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(1-18)20-9/h2-4, 6, 9, 18-19H, 1H2, (H2, 13, 15, 16)/t3-, 4+, 6-, 9+/m0/s1 SMILES Code: O[CH]1[CH](CO)O[CH](N2C=NC3=C(N)N=C(Cl)N=C23)[CH]1F
Synonyms	C1-F-Ara-A; Clofarabine, C1 F-Ara-A; C1 F-Ara-A; trade names: Clofarex; Clolar. Abbreviation: CAFdA

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Amount: 500mg

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