« Back
Home /
tafamidis-meglumine

tafamidis-meglumine

Item no.	V14470-100mg
Manufacturer	InvivoChem LLC
CASRN	951395-08-7
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V14470CAS #:951395-08-7Purity >=98% Description: Tafamidis meglumine (also known as Fx-1006 or PF-06291826), a potent and selectivetransthyretin (TTR) stabilizer, is a drug for the amelioration oftransthyretin-related hereditary amyloidosis (also familial amyloidpolyneuropathy, or FAP), a rare but deadly neurodegenerative disease. Itshows comparable potency and efficacy to the mutumant homotetramersV30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 uM.Tafamidis inhibits amyloidogenesis. The drug was approved by theEuropean Medicines Agency in November 2011 and by the JapanesePharmaceuticals and Medical Devices Agency in September 2013. Tafamidisfunctions by kinetic stabilization of the correctly folded tetramericform of the transthyretin (TTR) protein. References: Proc Natl Acad Sci U S A, 2012. 109(24): p. 9629-34. Related CAS: 951395-08-7 (meglumine salt) 594839-88-0 (free acid) Description: Tafamidis meglumine (also known as Fx-1006 or PF-06291826), a potent and selectivetransthyretin (TTR) stabilizer, is a drug for the amelioration oftransthyretin-related hereditary amyloidosis (also familial amyloidpolyneuropathy, or FAP), a rare but deadly neurodegenerative disease. Itshows comparable potency and efficacy to the mutumant homotetramersV30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 uM.Tafamidis inhibits amyloidogenesis. The drug was approved by theEuropean Medicines Agency in November 2011 and by the JapanesePharmaceuticals and Medical Devices Agency in September 2013. Tafamidisfunctions by kinetic stabilization of the correctly folded tetramericform of the transthyretin (TTR) protein. References: Proc Natl Acad Sci U S A, 2012. 109(24): p. 9629-34. Related CAS: 951395-08-7 (meglumine salt) 594839-88-0 (free acid)

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 100mg

available

Delivery expected until 9/6/2024