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Description: Flunarizine 2HCl (formerly R-14950; KW3149; R14950; KW 3149; trade name Sibelium), the dihydrochloride salt form of Flunarizine, is a selective calcium entry/channel blocker with calmodulin bindingproperties and anti-histamine H1 activity. It inhibits alcium channel with a Ki of 68 nM. Flunarizine has been approved for use in theprophylaxis of migraine, occlusive peripheral vascular disease, vertigoof central and peripheral origin, and as an adjuvant in the therapy ofepilepsy.
References: Biochem Pharmacol. 1983 Mar 1; 32(5):765-71; Res Commun Chem Pathol Pharmacol. 1988 Nov; 62(2):147-60.
Related CAS: 30484-77-6 (HCl); 52468-60-7 (fee base); 22348-32-9 (2HCl)
Chemical Name: 1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride
InChi Key: RXKMOPXNWTYEHI-RDRKJGRWSA-N
InChi Code: InChI=1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21; ; /h1-15, 26H, 16-20H2; 2*1H/b7-4+; ;
SMILES Code: FC1=CC=C(C(N2CCN(C/C=C/C3=CC=CC=C3)CC2)C4=CC=C(F)C=C4)C=C1.[H]Cl.[H]Cl
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