sn-38

Item no.	V1397-500mg
Manufacturer	InvivoChem LLC
CASRN	86639-52-3
Amount	500mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1397CAS #:86639-52-3 Purity >=98% Description: SN-38 (NK012; SN-38; NK-012; SN 38; 10-hydroxy-7-ethylcamptothecin) is the active metabolite of Irinotecan (CPT-11) which is a Topoisomerase I inhibitor approved for use as an anticancer drug. SN-38 exhibits 1000 times higher activity than irinoteca and acts by inhibiting DNA topoisomerase I, DNA synthesis and causing frequent DNA single-strand breaks. Description: References: Cancer Res. 1991 Aug 15; 51(16):4187-91; Cancer Chemother Pharmacol. 1997; 40(3):259-65. References: Related CAS#: 136572-09-3 (irinotecan HCl trihydrate); 100286-90-6 (irinotecan HCl); 97682-44-5 (irinotecan Free base)
Molecular Weight (MW)	392.4
Formula	C22H20N2O5
CAS No.	86639-52-3 (SN-38);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 21 mg/mL (53.5 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	Chemical Name: (S)-4, 11-diethyl-4, 9-dihydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione InChi Key: FJHBVJOVLFPMQE-QFIPXVFZSA-N InChi Code: InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16, 28)4-2/h5-8, 25, 28H, 3-4, 9-10H2, 1-2H3/t22-/m0/s1 SMILES Code: O=C1[C](O)(CC)C2=C(CO1)C(N3CC4=C(CC)C5=CC(O)=CC=C5N=C4C3=C2)=O
Synonyms	NK 012; SN38; NK-012; SN-38; NK012; SN 38; 10-hydroxy-7-ethylcamptothecin; irinotecan metabolite.

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