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Description: Pirfenidone (formerly AMR69; S7701, AMR-69; S-7701; trade name: Pirespa; Pirfenex; Deskar, Esbriet) is a potent inhibitor for TGF-beta production and TGF-beta stimulated collagen production with anti-fibrotic and anti-inflammatory properties. It has been used as a medication for the treatment of idiopathic pulmonary fibrosis. It reduces production of TNF-alpha and IL-1beta, and also has anti-fibrotic and anti-inflammatory properties. Pirfenidone is an anti-fibrotic drug for the treatment of idiopathic pulmonary fibrosis (IPF). It works by reducing lung fibrosis through downregulation of the production of growth factors and procollagens I and II.
References: Eur J Pharmacol. 2002 Jun 20; 446(1-3):177-85; Am J Transplant. 2002 Feb; 2(2):111-9.
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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