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Description: SB525334 (SB-525334; SB 525334) is a potent and selective inhibitor of TGF-beta (transforming growth factor-beta) receptor I, ALK5 (activin receptor-like kinase) with potential anti-fibrotic activity. It inhibits TGF-beta with an IC50 of 14.3 nM in a cell-free assay. SB525334 is 4-fold less potent to ALK4 than ALK5 and is inactive against ALK2, 3, and 6. In cell-based assays, SB-525334 at the concentration of 1 uM blocked TGF-beta1-induced phosphorylation and nuclear translocation of Smad2/3 in renal proximal tubule cells and inhibited TGF-beta1-induced increases in plasminogen activator inhibitor-1 (PAI-1) and procollagen alpha1(I) mRNA expression in A498 renal epithelial carcinoma cells.
References: J Pharmacol Exp Ther. 2005 Jun; 313(3):943-51; Am J Pathol. 2009 Feb; 174(2):380-9.
SB 525334; SB-525334; SB525334
Chemical Name: 6-(2-(tert-butyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline
SMILES Code: CC1=CC=CC(C2=C(C3=CC=C4N=CC=NC4=C3)N=C(C(C)(C)C)N2)=N1
Exact Mass: 343.1797
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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