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r-547-mesylate

r-547-mesylate

Item no.	V13562-250mg
Manufacturer	InvivoChem LLC
CASRN	869369-26-6
Amount	250mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V13562CAS #:869369-26-6Purity >=98% Description: R547 mesylate (Ro 4584820) is a potent, selective and ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3alpha/beta, while inactive to other kinases. R547 inhibited the proliferation of tumor cell lines and is active in all 19 cell lines tested irrespective of tissue of origin, multidrug resistance (MDR), p53, or retinoblastoma status. R547 possessing both 5-and 6-fluoro substitution culminated in an Inhibitor with low, single-digit nanomolar potency against the CDKs and excellent cellular potency (IC50=0.08 uM, HCT116 cell line). References: Mol Cancer Ther. 2006 Nov; 5(11):2644-58; J Med Chem. 2006 Nov 2; 49(22):6549-60. Related CAS #: 869369-26-6 (mesylate) 741713-40-6 (free base)

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 250mg

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