sant-1

Item no.	V1340-5mg
Manufacturer	InvivoChem LLC
CASRN	304909-07-7
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	304909-07-7
Available
Description	InvivoChem Cat #:V1340CAS #:304909-07-7Purity >=98% Description: SANT-1 (SANT1; SANT 1) is a novel, potent and selective Sonic hedgehog (Shh) enzyme inhibitor/Smo antagonist with potential antineoplastic activity. It inhibits Sonic hedgehog (Shh) enzyme with IC50s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 assay, respectively. It has potential anticancer activities by directly binding to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibiting Smo agonist effects with IC50 of 20 NM. Sonic hedgehog (Shh) is expressed in AML biopsies and is essential for the drug resistance of cancer stem cells of AML. Description: References: Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14071-6; PLoS One. 2009; 4(4):e5182. References:
Molecular Weight (MW)	373.49
Formula	C23H27N5
CAS No.	304909-07-7
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 21 mg/mL (56.2 mM)
	Water:< 1 mg/mL
	Ethanol: 20 mg/mL (53.5 mM)
Other info	Chemical Name: N-[(3, 5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine InChi Key: FOORCIAZMIWALX-JJIBRWJFSA-N InChi Code: InChI=1S/C23H27N5/c1-19-23(20(2)28(25-19)22-11-7-4-8-12-22)17-24-27-15-13-26(14-16-27)18-21-9-5-3-6-10-21/h3-12, 17H, 13-16, 18H2, 1-2H3/b24-17+ SMILES Code: CC1=C(/C=N/N2CCN(CC3=CC=CC=C3)CC2)C(C)=NN1C4=CC=CC=C4
Synonyms	SANT-1; SANT 1; SANT1

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