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ldn-57444

ldn-57444

Item no.	V1326-250mg
Manufacturer	InvivoChem LLC
CASRN	668467-91-2
Amount	250mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1326CAS #:668467-91-2Purity >=98% Description: LDN-57444 (LDN57444; LDN 57444) is a potent, reversible, and competitive proteasome inhibitor for Uch-L1 (ubiquitin C-terminal hydrolase-L1) with the potential to treat PD-Parkinson's disease. It inhibits Uch-L1 with an IC50 of 0.88 uM, and exhibted 28-fold selectivity over closely related isoform Uch-L3. Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) is an intracellular protein abundantly expressed in neurons, and a mutation in UCH-L1 has been identified in familial Parkinson's disease. Besides Uch-L1, LDN 57444 also inhibits Uch-L3 with a higher IC50 value of 25uM. Description: References: Cell. 2006 Aug 25; 126(4):775-88; Mol Cell Biochem. 2008 Nov; 318(1-2):109-15. References:
Molecular Weight (MW)	397.64
Formula	C17H11Cl3N2O3
CAS No.	668467-91-2
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 11 mg/mL (27.7 mM)
	Water:< 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: (Z)-3-(acetoxyimino)-5-chloro-1-(2, 5-dichlorobenzyl)indolin-2-one. InChi Key: OPQRFPHLZZPCCH-PGMHBOJBSA-N InChi Code: InChI=1S/C17H11Cl3N2O3/c1-9(23)25-21-16-13-7-12(19)3-5-15(13)22(17(16)24)8-10-6-11(18)2-4-14(10)20/h2-7H, 8H2, 1H3/b21-16- SMILES Code: O=C1N(CC2=CC(Cl)=CC=C2Cl)C3=C(C=C(Cl)C=C3)/C1=N/OC(C)=O
Synonyms	LDN57444; LDN 57444; LDN-57444.

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Amount: 250mg

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Delivery expected until 9/6/2024

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