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Description: BPDBA is a novel, potent and noncompetitive inhibitor of the betaine/GABA transporter 1 (BGT1) with the potential for treating epilepsy. BGT1 has emerged as an interesting target for treating epilepsy due to animal studies that reported anticonvulsant effects for the GAT1/BGT1 selective inhibitor EF1502 and the BGT1 selective inhibitor RPC-425.
References: https://pubmed.ncbi.nlm.nih.gov/31108110/; Structure-Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/gamma-Aminobutyric Acid Transporter 1 (BGT1). J Med Chem. 2017 Nov 9; 60(21):8834-8846. doi: 10.1021/acs.jmedchem.7b00924. Epub 2017 Oct 19. PubMed PMID: 28991462.
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