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zosuquidar-ly335979-3hcl

zosuquidar-ly335979-3hcl

Manufacturer	InvivoChem LLC
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
Amount	10mg
Item no.	V1294-10mg
CASRN	167465-36-3
eClass 6.1	32160405
eClass 9.0	32160490
Available
Description	InvivoChem Cat #:V1294CAS #:167465-36-3 Purity >=98% Description: Zosuquidar 3HCl (formerly D-06387; D06387; RS33295198; LY335979; LY-335979; RS-33295198), the trihydrochloride salt of zosuquidar, is a novel and potent inhibitor P-glycoprotein (P-gp) and modulator of P-gp-mediated multi-drug resistance with potential antitumor activity. It inhibits P-gp with a Ki of 60 nM in a cell-free assay. References: Cancer Res. 1996 Sep 15; 56(18):4171-9; BMC Cancer. 2008 Feb 13; 8:51. doi: 10.1186/1471-2407-8-51. Related CAS#: 167354-41-8 (free base); 167465-36-3 ( HCl)
Molecular Weight (MW)	636.99
Formula	C32H31F2N3O2.3HCl
CAS No.	167465-36-3(3HCl);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (157 mM)
	Water: 23 mg/mL (36.1 mM)
	Ethanol:< 1 mg/mL
Solubility (In vivo)	30% PEG400+0.5% Tween80+5% propylene glycol: 30 mg/mL
Synonyms	RS 33295-198 (D06387) 3HCl; LY335979; D-06387; D 06387; RS33295198; LY 335979; LY-335979; RS 33295198; Zosuquidar HCl; Zosuquidar 3HCl; Zosuquidar trihydrochloride

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