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tributyrin

tributyrin

Item no.	V12744-100g
Manufacturer	InvivoChem LLC
CASRN	60-01-5
Amount	100g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V12744CAS #: 60-01-5Purity >=98% Description: Tributyrin (Glyceryl tributyrate; NSC661583) is a neutral short-chain fatty acid triglyceride which is a stable and rapidlyabsorbed prodrug of Butyric Acid. Tributyrin diffuses through biologicalmembranes and is metabolized by intracellular lipases, releasingeffective butyrate directly into the cell in vivo. Tributyrin has potentantiproliferative, proapoptotic and differentiation-inducing effects. References: 1. TGaschott, et al. Tributyrin, a stable and rapidly absorbed prodrug ofbutyric acid, enhances antiproliferative effects ofdihydroxycholecalciferol in human colon cancer cells. J Nutr. 2001Jun; 131(6):1839-43. 2. ClaudiaP Schröder, et al. Tributyrin-induced differentiation promotesapoptosis of LS 174T colon cancer cells in vitro. Int J Oncol. 2002Jan; 20(1):195-200. 3. Transcriptomic responses provide a new mechanistic basis for the chemopreventive effects of folic acid and tributyrin in rat liver carcinogenesis. Int J Cancer. 2014 Jul 1; 135(1):7-18.

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