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banoxantrone-aq4n

banoxantrone-aq4n

Item no.	V12279-100mg
Manufacturer	InvivoChem LLC
CASRN	136470-65-0
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V12279CAS #:136470-65-0Purity >=98% Description: Banoxantrone (AQ4N) is a novel and potent bioreductive prodrug that can be reduced under hypoxia to a stable, DNA-affinic compound AQ4 (CAS#: 70476-63-0), which is a potent topoisomerase II inhibitor with antineoplastic activity. Banoxantrone intercalates into and crosslinks DNA, and inhibits topoisomerase II. This results in an inhibition of DNA replication and repair in tumor cells. Combined with conventional therapeutic agents, both oxygenic and hypoxic regions of tumors can be targeted. with antineoplastic activity References: 1. Hejmadi MV, et al. DNA damage following combination of radiation with the bioreductive drug AQ4N: possible selective toxicity to oxic and hypoxic tumour cells. Br J Cancer. 1996 Feb; 73(4):499-505. 2. Manley E Jr, et al. Impact of tumor blood flow modulation on tumor sensitivity to the bioreductive drug banoxantrone. J Pharmacol Exp Ther. 2013 Feb; 344(2):368-77. 3. Williams KJ, et al. In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts. Mol Cancer Ther. 2009 Dec; 8(12):3266-75. Related CAS: 136470-65-0 (Free base); 70476-63-0 (AQ4); 252979-56-9 (2HCl)

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Amount: 100mg

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Delivery expected until 9/6/2024

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