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bepotastine-besilate

bepotastine-besilate

Item no.	V1212-50mg
Manufacturer	InvivoChem LLC
CASRN	190786-44-8
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1212CAS #:190786-44-8Purity >=98% Description: Bepotastine besilate (bepotastine besylate; TAU-284; TAU284; Bepreve; Talion), the besylate salt of Bepotastine, is a 2nd generation, non-sedating, and selective antagonist of histamine 1 (H1) receptor with a pIC50 of 5.7. Bepostatine besilate has been approved to treat allergic rhinitis and urticaria and pruritus. Bepotastine besilate inhibits the action of histamine by blocking histamine H1 receptors, antagonising the vasoconstrictor, and to a lesser extent, the vasodilator effects of histamine. Mast cell stabilisers inhibit degranulation and consequently the release of histamine by interrupting the normal chain of intracellular signals. The brand of Bepostatine besilate is Talion. Description: References: Drug Metab Dispos. 2006 May; 34(5):793-9; Eur J Pharmacol. 2006 Oct 10; 547(1-3):59-64. References: Related CAS #:125602-71-3 (free base) 190786-44-8 (besylate) 1160415-45-1 (tosylate)
Molecular Weight (MW)	547.06
Formula	C21H25ClN2O3.C6H6O3S
CAS No.	190786-44-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 109 mg/mL (199.2 mM)
	Water:< 1 mg/mL
	Ethanol:< 1 mg/mL
Other info	Chemical Name: (S)-4-(4-((4-chlorophenyl)(pyridin-2-yl)methoxy)piperidin-1-yl)butanoic acid compound with benzenesulfonic acid (1:1) InChi Key: UDGHXQPQKQPSBB-BOXHHOBZSA-N InChi Code: InChI=1S/C21H25ClN2O3.C6H6O3S/c22-17-8-6-16(7-9-17)21(19-4-1-2-12-23-19)27-18-10-14-24(15-11-18)13-3-5-20(25)26; 7-10(8, 9)6-4-2-1-3-5-6/h1-2, 4, 6-9, 12, 18, 21H, 3, 5, 10-11, 13-15H2, (H, 25, 26); 1-5H, (H, 7, 8, 9)/t21-; /m0./s1 SMILES Code: OC(CCCN1CCC(O[CH](c2ncccc2)c3ccc(Cl)cc3)CC1)=O.OS(=O)(c4ccccc4)=O
Synonyms	TAU 284; Bepotastine besylate; bepotastine besilate; TAU-284; TAU284; Bepreve; Talion.

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Amount: 50mg

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