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ap20187

ap20187

Item no.	V11419-5mg
Manufacturer	InvivoChem LLC
CASRN	195514-80-8
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V11419CAS #:195514-80-8Purity >=98% Description: AP20187 (B/B Homodimerizer) is a novel cell-permeable and chemical inducer of dimerization, used to dimerize FK506-binding protein (FKBP) fusion proteins and initiate biological signaling cascades and gene expression or disrupt protein-protein interactions. AP20187-mediated activation of a chimeric insulin receptor results in insulin-like actions in skeletal muscle and liver of diabetic mice. References: 1. AhmedS, et al. Photocleavable dimerizer for the rapid reversal of moleculartrap antagonists. J Biol Chem. 2014 Feb 21; 289(8):4546-52. 2. LinW, et al. Oligodendrocyte-specific activation of PERK signalingprotects mice against experimental autoimmune encephalomyelitis. JNeurosci. 2013 Apr 3; 33(14):5980-91. 3. HaasME, et al. The Role of Proprotein Convertase Subtilisin/Kexin Type 9 inNephrotic Syndrome-Associated Hypercholesterolemia. Circulation. 2016Jul 5; 134(1):61-72.

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Amount: 5mg

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Delivery expected until 9/6/2024