apcin

Item no.	V11261-100mg
Manufacturer	InvivoChem LLC
CASRN	300815-04-7
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V11261CAS #:300815-04-7Purity >=98% Description: Apcin is a ligand of Cdc20 and a potent and competitive inhibitor of the E3 ligase activity anaphase-promoting complex/cyclosome (APC/C). It acts by blocking mitotic exit and being synergistically amplified by co-addition of Ts-Arg-OMe. Apcin competitively inhibits APC/C-dependent ubiquitylation by bindingto Cdc20 and preventing substrate recognition. Apcin occupes theD-box-binding pocket on the side face of the WD40-domain and can prolongmitosis. References: 1. KatharineL Sackton, et al. Synergistic blockade of mitotic exit by two chemicalinhibitors of the APC/C. Nature. 2014 Oct 30; 514(7524):646-9. 2. KatherineV Richeson, et al. Paradoxical mitotic exit induced by a small moleculeinhibitor of APC/C Cdc20. Nat Chem Biol. 2020 May; 16(5):546-555. 3. SusanneLub, et al. Inhibiting the anaphase promoting complex/cyclosome inducesa metaphase arrest and cell death in multiple myeloma cells.Oncotarget. 2016 Jan 26; 7(4):4062-76.

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Amount: 100mg

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Delivery expected until 9/6/2024