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dizocilpine-maleate-[-mk-801-maleate]

dizocilpine-maleate-[-mk-801-maleate]

Item no.	V1081-5mg
Manufacturer	InvivoChem LLC
CASRN	121917-57-5
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	121917-57-5
Available
Description	InvivoChem Cat #:V1081CAS #:121917-57-5 Purity >=98% Description: (-)-Dizocilpine Maleate also known as (-)-MK-801; MK801; MK 801, the maleate salt of dizocilpine, is a novel, potent, selective and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist with potential to treat a wide range of neurodegenerative conditions or disorders in which NMDA receptors play an important role. Dizocilpine inhibits NMDA with a Ki of 30.5 nM, and shows potent anti-convulsant, anti-anxiolytic and sympathomimetic activities. MK 801 can penetrate into the central nervous system. In the in vitro assay, MK 801 binds to rat cerebral cortical membrane with high affinity in a saturable manner. Description: wide range of neurodegenerative conditions or disorders in which NMDA receptors play an important role References: Proc Natl Acad Sci U S A. 1986 Sep; 83(18):7104-8; J Neurosurg Anesthesiol. 2006 Oct; 18(4):240-6. References: Related CAS#: 77086-22-7 (+)-MK-801; 77086-21-6 (free base)
Molecular Weight (MW)	337.37
Formula	C20H19NO4
CAS No.	121917-57-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 67 mg/mL (198.6 mM)
	Water: < 1 mg/mL
	Ethanol: 7 mg/mL (20.7 mM)
Solubility (In vivo)	30% PEG400+0.5% Tween80+5% propylene glycol: 15 mg/mL
Synonyms	MK801; MK 801; Dizocilpine; MK-801; MK 801 Maleate

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