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bufexamac-bufexamic-acid

bufexamac-bufexamic-acid

Item no.	V1063-5g
Manufacturer	InvivoChem LLC
CASRN	2438-72-4
Amount	5g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1063CAS #:2438-72-4Purity >=98% Description: Bufexamac (formerly also known as CP-1044-J-3; CP1044J3; Droxaryl; Parfenac; Bufexamic acid), a non-steroidal anti-inflammatory drug/NSAID, is a potent COX enzyme inhibitor with potential anti-inflammatory activity. It inhibits IFN-alpha release with an EC50 of 8.9 uM. Bufexamac is also a specific inhibitor of class IIB HDAC (histone deacetylases) (HDAC6/10). Treatment of peripheral blood mononuclear cells with bufexamac blocks the secretion of the inflammatory cytokine IFN-alpha. Bufexamac is a frequent and relevant contact sensitizer and also used as an anti-inflammatory agent belong to the NSAID (non-steroidal anti-inflammatory drug) class. Description: References: Nat Biotechnol. 2011 Mar; 29(3):255-65. References:
Molecular Weight (MW)	223.27
Formula	C12H17NO3
CAS No.	2438-72-4
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 45 mg/mL (201.5 mM)
	Water: < 1 mg/mL
	Ethanol: 3 mg/mL (13.4 mM)
Other info	Chemical Name: 2-(4-butoxyphenyl)-N-hydroxyacetamide InChi Key: MXJWRABVEGLYDG-UHFFFAOYSA-N InChi Code: InChI=1S/C12H17NO3/c1-2-3-8-16-11-6-4-10(5-7-11)9-12(14)13-15/h4-7, 15H, 2-3, 8-9H2, 1H3, (H, 13, 14) SMILES Code: O=C(NO)CC1=CC=C(OCCCC)C=C1
Synonyms	CP 1044 J 3; Bufexamic acid; CP-1044-J-3; CP1044J3; Droxaryl; Parfenac

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