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Description: Pranoprofen (also known as Pyranoprofen), a potent and approved non-steroidal anti-inflammatory drugs (NSAIDs), is a COX inhibitor that has been used as an anti-inflammatory drug in ophthalmology. It inhibits ER stress-induced glucose regulated protein 78 (GRP78) expression, an ER-localized molecular chaperon. Pranoprofen also inhibits ER stress-induced CCAAT/enhancer-binding protein homologous protein (CHOP) expression, an apoptotic transcription factor.
References: Neurochem Int. 2009 Jan; 54(1):1-6; J Pharmacobiodyn. 1990 Dec; 13(12):739-44.
InChi Key: TVQZAMVBTVNYLA-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H13NO3/c1-9(15(17)18)10-4-5-13-12(7-10)8-11-3-2-6-16-14(11)19-13/h2-7, 9H, 8H2, 1H3, (H, 17, 18)
SMILES Code: CC(C1=CC(CC2=CC=CN=C2O3)=C3C=C1)C(O)=O
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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