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sb-271046-sb-271046a

sb-271046-sb-271046a

Item no.	V0984-5mg
Manufacturer	InvivoChem LLC
CASRN	209481-20-9
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	209481-20-9
Available
Description	InvivoChem Cat #:V0984CAS #:209481-20-9 Purity >=98% Description: SB271046 (SB 271046; SB-271046; SB-271046A; SB271046A) is a novel, potent, selective and orally bioactive 5-HT6 receptor antagonist with important biological activity. It inhibits 5-HT6 with a pKi of 8.9, and exhibits 200-fold greater selectivity over other 5-HT receptor subtypes. SB-271046 substituted 125I-SB-258585 and 3H-LSD from human 5-HT6 receptors which recombinantly expressed in HeLa cells in vitro. SB-271046 also transfered 125I-SB-258585 from human caudate putamen and rat and pig striatum membranes. By 5-HT alone or after increasing concentrations of SB-271046 (10, 30, 100 and 300 nM) stimulates adenylyl cyclase activity in HeLa cells stably expressing human 5-HT6 receptors. Description: References: Br J Pharmacol. 2000 Aug; 130(7):1606-12; J Med Chem. 1999 Jan 28; 42(2):202-5. References: Related CAS: 209481-24-3 (HCl salt)
Molecular Weight (MW)	451.99
Formula	C20H22ClN3O3S2
CAS No.	209481-20-9(free base);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 40 mg/mL (81.9 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	1% methylcellulose: ca.30 mg/mL
Synonyms	SB-271046; SB 271046; SB271046; SB-271046 HCl; SB-271046 hydrochloride
SMILES Code	O=S(C1=C(C)C2=CC(Cl)=CC=C2S1)(NC3=CC=C(OC)C(N4CCNCC4)=C3)=O.[H]Cl

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Amount: 5mg

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Delivery expected until 9/6/2024