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Description: Dapoxetine HCl (formerly known as LY210448; LY-210448; trade name Priligy), an antidepressant, is a novel, potent, short-acting and selective serotonin reuptake inhibitor (SSRI) that has alto been used for the treatment of premature ejaculation. It is a short-acting novel selective serotonin reuptake inhibitor marketed for the treatment of premature ejaculation in men. Granisetron blocks the delayed rectifier current (IK) of feline isolated ventricular myocytes with a KD of 4.3 mM. Granisetron shows an intrinsic voltage-dependence as the block increases with depolarization.
References: Neuropharmacology. 2012 Jun; 62(7):2261-6; Naunyn Schmiedebergs Arch Pharmacol. 2012 Jul; 385(7):707-16.
Related CAS: 119356-77-3 (free base)
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