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rosuvastatin-calcium

rosuvastatin-calcium

Item no.	V0925-5g
Manufacturer	InvivoChem LLC
CASRN	147098-20-2
Amount	5g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0925CAS #:147098-20-2 Purity >=98% Description: Rosuvastatin Calcium (S-4522, Rosuvastatin hemicalcium; ZD-4522; ZD4522, trade name: Crestor), a member of the statin class of lipid-lowering drugs, is a potent and competitive inhibitor of HMG-CoA reductase with potential anti-hyperlipidemic activity. It inhibits HMG-CoA reductase with an IC50 of 11 nM in a cell-free assay. Rosuvastatin belongs to the statin class that hasd been approved for use in the treatment of high cholesterol and related conditions such as dyslipidemia, and to prevent cardiovascular disease. Its approximate elimination half life is 19 h and its time to peak plasma concentration is reached in 3–5 h following oral administration. In 2013 Crestor was the fourth-highest selling drug in the United States, accounting for approx. $5.2 billion in sales. Description: References: Clin Pharmacol Ther. 2004 May; 75(5):455-63; Bioorg Med Chem. 1997 Feb; 5(2):437-44. References: Related CAS: 1279031-70-7 (Rosuvastatin D3 Sodium); N/A (Rosuvastatin D6 Calcium); N/A ( Rosuvastatin D6 Sodium); 287714-41-4 (Rosuvastatin)
Molecular Weight (MW)	500.57
Formula	C22H28FN3O6S.1/2Ca
CAS No.	147098-20-2 (calcium);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (199.8 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	4% DMSO+30% PEG 300+dd H2O: 10 mg/mL
Synonyms	ZD 4522; Rosuvastatin calcium; S-4522; Rosuvastatin hemicalcium; ZD-4522; ZD4522; S 4522; S4522; ZD 4522 calcium salt; ZD 4522 Calcium; Brand name: Crestor.
Chemical Name	calcium (3R, 5S, E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3, 5-dihydroxyhept-6-enoate
SMILES Code	CC(C1=NC(=NC(=C1/C=C/C(O)CC(O)CC(=O)[O-])C2=CC=C(C=C2)F)N(S(=O)(=O)C)C)C.CC(C1=NC(=NC (=C1/C=C/C(O)CC(O)CC(=O)[O-])C2=CC=C(C=C2)F)N(S(=O)(=O)C)C)C.[Ca+2]

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