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pf-04620110

pf-04620110

Item no.	V0922-10mg
Manufacturer	InvivoChem LLC
CASRN	1109276-89-2
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0922CAS #:1109276-89-2Purity >=98% Description: PF-04620110 (PF04620110; PF 04620110) is a novel, potent, orally bioactive, and selective diglyceride acyltransferase-1 (DGAT1) inhibitor with the potential to treat type 2 diabetes mellitus. It inhibits DGAT1 with an IC50 of 19 nM. PF-04620110 has been advanced to clinical trials on the basis of the excellent pharmacologic and pharmacokinetic profiles. F-04620110 shows high selectivity versus a broad panel of off-target pharmacologic end points. In vivo DGAT-1 inhibition has been demonstrated through reduction of plasma triglyceride levels in rodents at doses of >=0.1 mg/kg following a lipid challenge. Description: References: ACS Med Chem Lett. 2011; 2(5):407-12; Am J Physiol Gastrointest Liver Physiol. 2013; 304(11):G958-69. References:
Molecular Weight (MW)	396.44
Formula	C21H24N4O4
CAS No.	1109276-89-2
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 49 mg/mL (123.6 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other Info	Chemical Name: trans-4-[4-(4-Amino-7, 8-dihydro-5-oxopyrimido[5, 4-f][1, 4]oxazepin-6(5H)-yl)phenyl]-cyclohexaneacetic acid InChi Key: GEVVQZHMFVFGLN-HDJSIYSDSA-N InChi Code: InChI=1S/C21H24N4O4/c22-19-18-20(24-12-23-19)29-10-9-25(21(18)28)16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-17(26)27/h5-8, 12-14H, 1-4, 9-11H2, (H, 26, 27)(H2, 22, 23, 24)/t13-, 14- SMILES Code: O=C(O)C[CH]1CC[CH](C2=CC=C(N3CCOC4=NC=NC(N)=C4C3=O)C=C2)CC1
Synonyms	PF04620110. PF-4620110; PF-04620110; PF 04620110; PF 4620110; PF4620110.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10mg

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