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lb42708

lb42708

Item no.	V0921-5mg
Manufacturer	InvivoChem LLC
CASRN	226929-39-1
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	226929-39-1
Available
Description	InvivoChem Cat #:V0921CAS #:226929-39-1Purity >=98% Description: LB42708 (LB-42708; LB 42708) is a novel, potent, orally bioactive, and nonpeptidic farnesyltransferase (FTase) inhibitor with potential anti-inflammatory activity. It inhibits H-ras, N-ras, and K-ras with IC50 of 0.8, 1.2, and 2.0 nM, respectively. LB42708 demonstrates significant in vivo efficacy in mice collagen-induced arthritis model. Description: ice collagen-induced arthritis model. References: J Immunol. 2004 Jul 15; 173(2):1276-83; Toxicol Appl Pharmacol. 2006 Sep 15; 215(3):317-29; Mol Pharmacol. 2010 Jul; 78(1):142-50. References:
Molecular Weight (MW)	555.46
Formula	C30H27BrN4O2
CAS No.	226929-39-1
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (180.0 mM)
	Water: < 1 mg/mL
	Ethanol: 86 mg/mL warmed (154.8 mM)
Other info	Chemical Name: (1-((1-(4-bromobenzyl)-1H-imidazol-5-yl)methyl)-4-(naphthalen-1-yl)-1H-pyrrol-3-yl)(morpholino)methanone InChi Key: GUUIRIMAQGOLHT-UHFFFAOYSA-N InChi Code: InChI=1S/C30H27BrN4O2/c31-24-10-8-22(9-11-24)17-35-21-32-16-25(35)18-33-19-28(27-7-3-5-23-4-1-2-6-26(23)27)29(20-33)30(36)34-12-14-37-15-13-34/h1-11, 16, 19-21H, 12-15, 17-18H2 SMILES Code: O=C(C1=CN(CC2=CN=CN2CC3=CC=C(Br)C=C3)C=C1C4=C5C=CC=CC5=CC=C4)N6CCOCC6
Synonyms	LB-42708; LB 42708; LB42708;

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