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gossypol-acetate

gossypol-acetate

Item no.	V0871-1g
Manufacturer	InvivoChem LLC
CASRN	12542-36-8
Amount	1g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0871CAS #:12542-36-8Purity >=98% Description: Gossypol Acetate (Pogosin, AT101; BL-193; AT-101) is a naturally occuring polyphenolic aldehyde with potential anticancer activity. It inhibit Bcl-xL and Bcl-2 proteins with Kis of 0.5-0.6 uM and 0.2-0.3 mM, respectively. It also acts as an inhibitor for various dehydrogenase enzymes. Gossypol, a known antispermatogenic agent from the cotton plant genus Gossypium, was found to inhibit yellow perch sperm motility in vitro and lactate dehydrogenase activity in spermatozoa when used in a dose-dependent manner. Gossypol has been approved to have antiproliferative and apoptosis-inducing effects on some kinds of cancer cell lines in vitro. Description: References: Aquat Toxicol. 2000 Jun 1; 49(3):181-187; Oncol Rep. 2013 Aug; 30(2):731-8. References: Related CAS #: 303-45-7 (free) 12542-36-8 (acetic acid) 812542-36-8 (R-isomer acetic acid)
Molecular Weight (MW)	578.61
Formula	C32H34O10
CAS No.	12542-36-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (172.8 mM)
	Water: < 1 mg/mL
	Ethanol: 21 mg/mL (36.4 mM)
Solubility (In vivo)	Chemical Name: acetic acid compound with (S)-1, 1', 6, 6', 7, 7'-hexahydroxy-5, 5'-diisopropyl-3, 3'-dimethyl-[2, 2'-binaphthalene]-8, 8'-dicarbaldehyde (1:1) InChi Key: NIOHNDKHQHVLKA-UHFFFAOYSA-N InChi Code: InChI=1S/C30H30O8.C2H4O2/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36; 1-2(3)4/h7-12, 33-38H, 1-6H3; 1H3, (H, 3, 4) SMILES Code: O=CC1=C(O)C(O)=C(C(C)C)C2=CC(C)=[C]([C]3=C(C)C=C4C(C(C)C)=C(O)C(O)=C(C=O)C4=C3O)C(O)=C12.CC(O)=O
Synonyms	Pogosin, AT101; BL-193; AT-101; (+/-)-Gossypol-acetic acid; BL19; AT 101; 3BL 193 (acetic acid); Gossypol acetate; Gossypol acetic acid; Acetic acid Gossypol.

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