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Description: AGI-6780 (AGI6780; AGI 6780) is a potent and selective inhibitor of tumor-associated mutant IDH2 (isocitrate dehydrogenases 2) R140Q with potential anti-inflammatory activity. It inhibits IDH2 R140Q with an IC50 of 23 nM. It shows less potency against IDH2(WT) with an IC50 of 190+/-8.1 nM.
References: Science. 2013 May 3; 340(6132):622-6.
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