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avasimibe

avasimibe

Item no.	V0803-10mg
Manufacturer	InvivoChem LLC
CASRN	166518-60-1
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	166518-60-1
Available
Description	InvivoChem Cat #:V0803CAS #:166518-60-1Purity >=98% Description: Avasimibe (CI-1011; PD 148515; CI1011; CI 1011; PD148515; PD-148515) is a novel, potent and orally bioavailable inhibitor of acyl-Coenzyme A:cholesterol acyltransferase (ACAT) with the potential for the treatment of atherosclerosis and hyperlipidaemia. It inhibits ACAT1/2 with IC50s of 24 and 9.2 uM, respectively. It also inhibits human P450 isoenzymes CYP2C9, CYP1A2 and CYP2C19 with IC50 of 2.9 uM, 13.9 uM and 26.5 uM, respectively. Description: References: J Med Chem. 1996 Dec 20; 39(26):5031-4; Atherosclerosis. 1998 Jan; 136(1):79-87. References: Related CAS #: 166518-61-2 (sodium)
Molecular Weight (MW)	501.72
Formula	C29H43NO4S
CAS No.	166518-60-1
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (199.3 mM)
	Water: < 1 mg/mL
	Ethanol: 8 mg/mL (15.9 mM)
Solubility (In vivo)	2% DMSO+corn oil: 5mg/mL
Synonyms	CI1011; PD-148515; Avasimibe; PD 148515; CI-1011; CI 1011; PD148515; Avasimibe sodium.
SMILES Code	c1(C(C)C)cc(cc(c1CC(NS(Oc1c(cccc1C(C)C)C(C)C)(=O)=O)=O)C(C)C)C(C)C

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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