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Description: Andrographolide, a naturally occuring labdane diterpenoid extracted from the stem and leaves of Andrographis paniculata, is an irreversible/covalent NF-kappaB inhibitor with potential anti-inflammatory activity. It inhibits NF-kappaB activation by forming a covalent bond with the cysteine residue on p50 in endothelial cells.
References: J Immunol. 2004 Sep 15; 173(6):4207-17.
InChi Key: BOJKULTULYSRAS-WLRTZDKTSA-N
InChi Code: InChI=1S/C20H30O5/c1-12-4-7-16-19(2, 9-8-17(23)20(16, 3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5, 14-17, 21-23H, 1, 4, 6-11H2, 2-3H3/b13-5+
SMILES Code: O=C1OCC(O)/C1=C\CC2C(CCC3C(C)(CO)C(O)CCC23C)=C
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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