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pd-151746

pd-151746

Item no.	V0704-25mg
Manufacturer	InvivoChem LLC
CASRN	179461-52-0
Amount	25mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0704CAS #:179461-52-0Purity >=98% Description: PD 151746 (PD-151746) is a novel, potent, selective, and cell-permeable calpain inhibitor with important biological activity. It inhibits calpain with a Ki of 0.26 uM for u-Calpain, and has about 20-fold higher selectivity for u-calpain (Ki = 0.26 +/- 0.03 uM) over m-calpain (Ki = 5.33 +/- 0.77 uM). PD151746 significantly inhibited NMDA-induced alpha-spectrin breakdown product (SBDP) of 145 kDa and completely inhibited the fragmentation of calmodulin-dependent protein kinase II-alpha (CaMPK-IIalpha) and nitric oxide synthase (nNOS), which were cleaved by calpain. The u-calpain inhibitor PD 151746 decreases oxLDL-induced cytotoxicity. References: Proc Natl Acad Sci U S A. 1996 Jun 25; 93(13):6687-92; Biochem J. 2003 Sep 1; 374(Pt 2):403-11.
Molecular Weight (MW)	237.25
Formula	C11H8FNO2S
CAS No.	179461-52-0
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 47 mg/mL (198.1 mM)
	Water: < 1 mg/mL
	Ethanol: 47 mg/mL (198.1 mM)
Other info	Chemical Name: 3-(5-Fluoro-3-indolyl)-2-mercapto-2-propenoic Acid InChi Key: HWMQHECFXSVZGN-KMKOMSMNSA-N InChi Code: InChI=1S/C11H8FNO2S/c12-7-1-2-9-8(4-7)6(5-13-9)3-10(16)11(14)15/h1-5, 13, 16H, (H, 14, 15)/b10-3- SMILES Code: O=C(O)/C(S)=C/C1=CNC2=C1C=C(F)C=C2
Synonyms	PD 151746; PD151746; PD-151746;

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 25mg

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