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cgi1746

cgi1746

Item no.	V0646-250mg
Manufacturer	InvivoChem LLC
CASRN	910232-84-7
Amount	250mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0646CAS #:910232-84-7Purity >=98% Description: CGI1746 (CGI-1746) is a reversible/non-covalent and highly selective small-molecule inhibitor of the Bruton's tyrosine kinase-Btk with potential anti-inflammatory activity. It inhibits BTK with an IC50 of 1.9 nM. CGI-1746 shows high in vivo antiinflammatory efficacy in an anti-collagen II antibody–induced arthritis (CAIA) model in mice. Description: anti-collagen II antibody–induced arthritis (CAIA) model in mice. References: Nat Chem Biol. 2011 Jan; 7(1):41-50. References:
Molecular Weight (MW)	579.69
Formula	C34H37N5O4
CAS No.	910232-84-7
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (172.5 mM)
	Water: < 1 mg/mL
	Ethanol: 33 mg/mL warmed (56.9 mM)
Other info	Chemical Name: 4-(tert-butyl)-N-(2-methyl-3-(4-methyl-6-((4-(morpholine-4-carbonyl)phenyl)amino)-5-oxo-4, 5-dihydropyrazin-2-yl)phenyl)benzamide InChi Key: JIFCFQDXHMUPGP-UHFFFAOYSA-N InChi Code: InChI=1S/C34H37N5O4/c1-22-27(7-6-8-28(22)37-31(40)23-9-13-25(14-10-23)34(2, 3)4)29-21-38(5)33(42)30(36-29)35-26-15-11-24(12-16-26)32(41)39-17-19-43-20-18-39/h6-16, 21H, 17-20H2, 1-5H3, (H, 35, 36)(H, 37, 40) SMILES Code: O=C(NC1=CC=CC(C(N=C2NC3=CC=C(C(N4CCOCC4)=O)C=C3)=CN(C)C2=O)=C1C)C5=CC=C(C(C)(C)C)C=C5
Synonyms	CGI-1746; CGI 1746; CGI1746;

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Amount: 250mg

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