ag-1024

Description: AG-1024 (also called Tyrphostin or Tyrphostin AG1024) is a potent and selective inhibitor of IGF-1R (insulin-like growth factor-1) with potential antitumor activity. It selectively inhibits IGF-1R autophosphorylation with an IC50 of 7 uM, and is less potent against Insulin receptor-IR with an IC50 of 57 uM. AG-1024 shows significantl antitumor efficacy in a Ba/F3-p210 xenograft model in mice.

References: Endocrinology. 1997 Apr; 138(4):1427-33; Br J Cancer. 2001 Dec 14; 85(12):2017-21; Cancer Res. 2003 Mar 15; 63(6):1420-9.

Chemical Name: 2-(3-bromo-5-tert-butyl-4-hydroxybenzylidene)malononitrile

InChi Key: ABBADGFSRBWENF-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H13BrN2O/c1-14(2, 3)11-5-9(4-10(7-16)8-17)6-12(15)13(11)18/h4-6, 18H, 1-3H3

SMILES Code: N#C/C(C#N)=C/C1=CC(C(C)(C)C)=C(O)C(Br)=C1