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tyrphostin-ag-879

tyrphostin-ag-879

Item no.	V0582-25mg
Manufacturer	InvivoChem LLC
CASRN	148741-30-4
Amount	25mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0582CAS #:148741-30-4Purity >=98% Description: Tyrphostin AG 879 (AG-879), a tyrphostin compound, is novel multi-tyrosine kinase inhibitor with potential antitumor activity. It potently inhibits HER2/ErbB2 with an IC50 of 1 uM, shows 100- and 500-fold higher selectivity against ErbB2 over PDGFR and EGFR. Description: References: Cancer Res. 2005 Jul 1; 65(13):5848-56; Anticancer Drugs. 2006 Sep; 17(8):929-41. References
Molecular Weight (MW)	316.46
Formula	C18H24N2OS
CAS No.	148741-30-4
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 36 mg/mL (113.7 mM)
	Water: < 1 mg/mL
	Ethanol: 3 mg/mL (9.5 mM)
Solubility (In vivo)	1% DMSO+30% polyethylene glycol+1% Tween 80: 30 mg/mL
Synonyms	AG 879; Tyrphostin AG 879; Tyrphostin AG879; Tyrphostin AG-879; AG879; AG-879; Chemical Name: 2-Propenethioamide, 3-(3, 5-bis(1, 1-dimethylethyl)-4-hydroxyphenyl)-2-cyano-, (E)- InChi Key: XRZYELWZLNAXGE-KPKJPENVSA-N InChi Code: InChI=1S/C18H24N2OS/c1-17(2, 3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4, 5)6/h7-9, 21H, 1-6H3, (H2, 20, 22)/b12-7+ SMILES Code: S=C(N)/C(C#N)=C/C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1

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Amount: 25mg

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