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sennoside-b

sennoside-b

Item no.	V0578-500mg
Manufacturer	InvivoChem LLC
CASRN	128-57-4
Amount	500mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0578CAS #:128-57-4Purity >=98% Description: Sennoside B is a naturally occuring anthraquinone glycoside compound isolated from Puffer fish, salamanders, frogs foot spot et al., It is a type of irritant laxative used to treat constipation and may also be used for cleaning out the intestines before a bowel examination/surgery. Sennoside B inhibits PDGF-stimulated cell proliferation. Sennoside B was found to inhibit PDGF-BB-induced phosphorylation of the PDGFR in human MG63 osteosarcoma cells. Pre-incubation of PDGF-BB with sennoside B inhibited the phosphorylation of pathway components including AKT, STAT-5 and ERK1/2. Description: References: Chem Pharm Bull. 1989; 37(10):2744-6; Life Sci. 2009; 84(25-26):915-22; Pharmacology. 1988; 36 Suppl 1:180-7. References:
Molecular Weight (MW)	862.74
Formula	C42H38O20
CAS No.	128-57-4
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM
	Water: N/A
	Ethanol: N/A
Solubility (In vivo)	Chemical Name: (9R, 9'S)-4, 4'-dihydroxy-10, 10'-dioxo-5, 5'-bis(((2S, 3R, 4S, 5S, 6R)-3, 4, 5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-9, 9', 10, 10'-tetrahydro-[9, 9'-bianthracene]-2, 2'-dicarboxylic acid InChi Key: IPQVTOJGNYVQEO-AIFLABODSA-N InChi Code: InChI=1S/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38(54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20(28)46/h1-10, 23-26, 31-32, 35-38, 41-48, 51-54H, 11-12H2, (H, 55, 56)(H, 57, 58)/t23-, 24-, 25-, 26+, 31-, 32-, 35+, 36+, 37-, 38-, 41-, 42-/m1/s1 SMILES Code: [H][C]1([C](C2=C(C3=O)C(O[CH]4[CH](O)[CH](O)[CH](O)[CH](CO)O4)=CC=C2)(C5=C3C(O)=CC(C(O)=O)=C5)[H])C6=C(C(C7=C1C=CC=C7O[CH]8[CH](O)[CH](O)[CH](O)[CH](CO)O8)=O)C(O)=CC(C(O)=O)=C6
Synonyms	Sennoside B

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Amount: 500mg

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