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lenvatinib-e7080

lenvatinib-e7080

Item no.	V0508-100mg
Manufacturer	InvivoChem LLC
CASRN	417716-92-8
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0508CAS #:417716-92-8 Purity >=98% Description: Lenvatinib (formerly E-7080, ER-203492-00; trade name Lenvima among others) is a potent and orally bioavailable multi-targeted kinase VEGFR2(KDR)/VEGFR3(Flt-4) inhibitor with potential antitumor activity. It inhibits VEGFR2/VEGFR3 with IC50 values of 4 nM/5.2 nM, respectively, and is less potent against VEGFR1/Flt-1 in cell-free assays. Lenvatinib was approved in 2015 for the treatment of differentiated thyroid cancer that is either locally recurrent or metastatic, progressive, and did not respond to treatment with radioactive iodine (radioiodine). Description: References: Int J Cancer. 2008 Feb 1; 122(3):664-71; Clin Cancer Res. 2008 Sep 1; 14(17):5459-65. References: Related CAS: 857890-39-2 (mesylate)
Molecular Weight (MW)	426.85
Formula	C21H19ClN4O4
CAS No.	417716-92-8 (free base);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 40 mg/mL (93.7 mM)
	Water: < 1 mg/mL
	Ethanol:< 1 mg/mL
Solubility (In vivo)	0.5% methylcellulose: 30 mg/kg
Synonyms	E-7080; E7080; E 7080; ER-203492-00; Lenvatinib; Brand name Lenvima Chemical Name: 4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxamide SMILES Code: O=C(C1=C(OC)C=C2N=CC=C(OC3=CC=C(NC(NC4CC4)=O)C(Cl)=C3)C2=C1)N

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Amount: 100mg

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