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pexmetinib-arry-614

pexmetinib-arry-614

Item no.	V0484-500mg
Manufacturer	InvivoChem LLC
CASRN	945614-12-0
Amount	500mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0484CAS #:945614-12-0Purity >=98% Description: Pexmetinib (formerly ARRY614; ARRY-614) is a novel, potent, orally bioavailable, and dual inhibitor of p38 mitogen-activated protein kinase and Tie2 kinases with potential anti-inflammatory, anti-cancer and antiangiogenic activity. It inhibits p38 MAPK/Tie-2 kinases with IC50s of 4 nM/18 nM in a HEK-293 cell line. Description References: Clin Cancer Res. 2015 Mar 1; 21(5):985-94. References: Related CAS: 1416216-01-7 (HCl salt)
Molecular Weight (MW)	556.63
Formula	C31H33FN6O3
CAS No.	945614-12-0
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (179.6 mM)
	Water: < 1 mg/mL
	Ethanol: N/A
SMILES	O=C(NCC1=CC(F)=CC=C1OC2=CC3=C(N(CCO)N=C3)C=C2)NC4=CC(C(C)(C)C)=NN4C5=CC=C(C)C=C5
Synonyms	ARRY 614; ARRY614; ARRY-614; 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(5-fluoro-2-((1-(2-hydroxyethyl)-1H-indazol-5-yl)oxy)benzyl)urea

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500mg

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Delivery expected until 9/6/2024

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