Comparison

jnk-in-8

Item no. V0472-100mg
Manufacturer InvivoChem LLC
CASRN 1410880-22-6
Amount 100mg
Category
Type Biochemicals
Specific against other
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Available
Description
InvivoChem Cat #:V0472CAS #:1410880-22-6Purity >=98%

Description: JNK-IN-8 (JNK Inhibitor XVI; JNK-IN8) is the first irreversible/covalent inhibitor of pan-JNK (c-Jun N-terminal Kinase) with potential antitumor activity. It inhibits JNK1/2/4 by covalently binding to Cys116 in their catalytic sites with IC50s of 4.7 nM, 18.7 nM and 1 nM. JNK-IN-8 is a useful probe for exploring JNK-dependent signal transduction.

Description:

References: Chem Biol. 2012 Jan 27; 19(1):140-54; Biochem J. 2012 Jan 1; 441(1):339-46; Chem Biol. 2013 Feb 21; 20(2):146-59.

References:
Molecular Weight (MW)
507.59
Formula
C29H29N7O2
CAS No.
1410880-22-6
Storage
-20C for 3 years in powder form
-80C for 2 years in solvent
Solubility (In vitro)
DMSO: 100 mg/mL (197.0 mM)
Water: < 1 mg/mL
Ethanol:< 1 mg/mL
Solubility (In vivo)
2% DMSO+30% PEG 300+5% Tween 80+ddH2O: 10mg/mL
Synonyms

Synonym: JNK Inhibitor XVI; JNK-IN 8; JNK-IN8; JNK-IN 8; c-Jun N-terminal Kinase Inhibitor XVI.

Chemical Name: (E)-3-(4-(dimethylamino)but-2-enamido)-N-(3-methyl-4-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide

InChi Key: GJFCSAPFHAXMSF-UXBLZVDNSA-N

InChi Code: InChI=1S/C29H29N7O2/c1-20-17-24(11-12-25(20)34-29-31-15-13-26(35-29)22-8-5-14-30-19-22)33-28(38)21-7-4-9-23(18-21)32-27(37)10-6-16-36(2)3/h4-15, 17-19H, 16H2, 1-3H3, (H, 32, 37)(H, 33, 38)(H, 31, 34, 35)/b10-6+

SMILES Code: CN(C/C=C/C(NC1=CC=CC(C(NC2=CC=C(C(C)=C2)NC3=NC=CC(C4=CN=CC=C4)=N3)=O)=C1)=O)C

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100mg
Available: In stock
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