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fr-180204

fr-180204

Item no.	V0465-100mg
Manufacturer	InvivoChem LLC
CASRN	865362-74-9
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0465CAS #:865362-74-9Purity >=98% Description: FR-180204 (FR180204) is a novel, potent, selective and ATP-competitive inhibitor of ERK (extracellular signal-regulated kinase) with potential anti-inflammatory activity and has the potential to be used as a new therapy for rheumatoid arthritis. It inhibits ERK1 And ERK2 with Kis of 0.31 uM and 0.14 uM, respectively, and displays 30-fold higher selectivity for ERK over p38alpha (IC50 = 10 uM); It exhibits no/little activity against human recombinant MEK1, MKK4, IKKalpha, PKCalpha, Src, Syc and PDGFalpha at concentrations of > 30 uM. Description References: Biochem Biophys Res Commun. 2005 Oct 14; 336(1):357-63; Cell Physiol Biochem. 2012; 29(5-6):667-74. References:
Molecular Weight (MW)	327.34
Formula	C18H13N7
CAS No.	865362-74-9
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 65 mg/mL (198.6 mM)
	Water: < 1 mg/mL
	Ethanol: 2 mg/mL warmed (6.1 mM)
Other info	Chemical Name: 5-(2-phenylpyrazolo[1, 5-a]pyridin-3-yl)-1H-pyrazolo[3, 4-c]pyridazin-3-amine InChi Key: XVECMUKVOMUNLE-UHFFFAOYSA-N InChi Code: InChI=1S/C18H13N7/c19-17-12-10-13(20-22-18(12)23-21-17)15-14-8-4-5-9-25(14)24-16(15)11-6-2-1-3-7-11/h1-10H, (H3, 19, 21, 22, 23) SMILES Code: NC1=NNC2=NN=C(C3=C4C=CC=CN4N=C3C5=CC=CC=C5)C=C21
Synonyms	FR-180204; FR 180204; FR180204.

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Amount: 100mg

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